Abstract
IN 1941 research in prostatic cancer received great impetus from the discovery by Huggins and his associates 1 that remarkable regression occurred clinically in the primary neoplasm and its metastases after castration or administration of estrogen. These findings were subsequently verified by others. 2 Unfortunately, the gratifying improvement manifested by most patients treated in this manner has since been found to be only temporary, and no actual cures have ever been recorded. Furthermore, postmortem studies on patients in whom no palpable or roentgenologic evidence of local or distant recurrence was evident just before death have shown extensive involvement of the prostate, bones and soft tissues. In all cases in which radical perineal prostatectomy has been done for advanced cancer after preoperative administration of estrogen, malignant cells have been readily demonstrated in the surgical specimens. 3 We have thus been forced to conclude that although existing methods of endocrine manipulation have
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
