Abstract
BackgroundThe inverted (hobnail) variant of high-grade prostatic intraepithelial neoplasia (HGPIN) has been reported in two previous series and one case of inverted polarity in invasive adenocarcinoma has been reported. We reported an additional case of invasive carcinoma with this peculiar morphology.Case presentationWe reported an additional case of invasive carcinoma with this peculiar morphology. A prostatectomy specimen of a 64-year-old patient showed a GG2 adenocarcinoma with extensive intraprostatic perineural infiltration and extraprostatic extension. Half of the entire tumor showed a distinctive inverted morphology.ConclusionAlthough pseudohyperplastic adenocarcinoma is believed to be a low-grade tumor to be graded as Gleason pattern 3, awareness of this morphology is important to collect more information on its biologic behavior and clinical implication.
Highlights
The inverted variant of high-grade prostatic intraepithelial neoplasia (HGPIN) has been reported in two previous series and one case of inverted polarity in invasive adenocarcinoma has been reported
Conclusion: pseudohyperplastic adenocarcinoma is believed to be a low-grade tumor to be graded as Gleason pattern 3, awareness of this morphology is important to collect more information on its biologic behavior and clinical implication
We reported an additional case of invasive carcinoma with this peculiar morphology
Summary
The inverted (hobnail) variant of high-grade prostatic intraepithelial neoplasia (HGPIN) has been reported in two previous series and one case of inverted polarity in invasive adenocarcinoma has been reported. A prostatectomy specimen of a 64-year-old patient showed a GG2 adenocarcinoma with extensive intraprostatic perineural infiltration and extraprostatic extension. We reported an additional case of invasive carcinoma with this peculiar morphology Since these tumors are currently diagnosed as (low grade) pseudohyperplastic variant of prostatic adenocarcinoma, awareness of this morphology (or maybe sub-variant) is important to collect more data on the clinical implications of this distinctive morphology. Case presentation A 64-year-old patient sought urologic assistance due to an elevated serum Prostate Specific Antigen (PSA) level (7.2 ng/mL). PSA was undetectable in serum collected 45 days after surgery
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