Abstract
BackgroundAdenoid cystic carcinoma (AdCC) of the head and neck is an uncommon malignant epithelial tumour of the secretory glands. Many patients develop slowly growing local recurrence and/or distant metastasis, for which treatment options are limited. A retrospective analysis of 9 AdCC patients was conducted to analyse the visualization of AdCC on PSMA PET/CT and to investigate the expression of PSMA on primary, recurrent and metastatic AdCC tumour tissue using immunohistochemistry.ResultsLocal recurrence occurred in six patients and eight developed distant metastasis. All PET/CTs depicted PSMA-ligand uptake. Four PSMA PET/CTs showed suspected residual disease, eight scans depicted uptake in areas suspected of distant metastasis. Median Maximum Standardized Uptake Value (SUVmax) in local recurrent and distant metastatic AdCC was 2.52 (IQR 2.41–5.95) and 4.01 (IQR 2.66–8.71), respectively. All primary tumours showed PSMA expression on immunohistochemistry (5–90% expression), as well as all available specimens of local recurrence and distant metastases.ConclusionPSMA PET/CT is able to detect and visualize local recurrent and distant metastatic AdCC. PSMA-specific targeting is supported by PSMA expression on immunohistochemistry.
Highlights
Adenoid cystic carcinoma (AdCC) of the head and neck is an uncommon malignant epithelial tumour of the secretory glands
Data on the presence of Prostate Specific Membrane Antigen (PSMA) on AdCC are lacking, the aim of this study was to analyse the visualization of local recurrent or distant metastatic AdCC on PSMA PET/ CT and to investigate the expression of PSMA on AdCC tumour tissues, both primary and metastatic
Since 1990, fifty-six patients were diagnosed with AdCC at our institute, of which thirteen patients are in active follow-up because of local recurrent or distant metastatic disease
Summary
Adenoid cystic carcinoma (AdCC) of the head and neck is an uncommon malignant epithelial tumour of the secretory glands. Many patients develop slowly growing local recurrence and/or distant metastasis, for which treatment options are limited. Adenoid cystic carcinoma (AdCC) is an uncommon malignant epithelial tumour of the secretory glands in the head and neck region, accounting for approximately 20– 35% of all salivary gland malignancies [1, 2]. AdCC arises in the major salivary glands and more often in the minor salivary glands of the lip, oral cavity, oropharynx, nasopharynx, nasal cavity, paranasal sinus, larynx and tracheobronchial tree. It is seen in the lacrimal and ceruminous glands [1, 4, 5].
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