Abstract
e16557Background: Extracellular vesicles (EVs) may play an important role in cancer development and progression. We aimed to investigate the prognostic potential of prostate-specific EVs in prostat...
Highlights
The number of EVs observed by transmission electron microscope (TEM) was higher in prostate cancer cells than in BPH cells
Given the complexities of tumor heterogeneity and molecular evolution during the duration of treatment, a tissue biopsy sample may not be a true representation of the molecular profile of the individual patient
Unlike Prostate-specific antigen (PSA) screening or monitoring, which may not cancer-specific, we successfully demonstrated a difference in plasma prostate-specific EV concentration between BPH and Prostate cancer (PCa), together with differences in pathologic outcomes of PCa patients according to the plasma EV concentration
Summary
We aimed to investigate the prognostic potential of prostate-specific EVs in prostate cancer (PCa) patients. We aimed to investigate the levels of prostate-specific EVs isolated from the plasma of patients with benign prostatic hyperplasia (BPH) and PCa of different stage and grade and to evaluate the prognostic potential of prostate-specific EVs in PCa patients
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