Abstract
Improved procedures for measuring prostate-specific antigen (PSA) protein and mRNA have demonstrated that this kallikrein-like serine protease is present in many nonprostatic sources, indicating that PSA production/secretion is not tissue- or sex-specific, but rather is a steroid hormone-dependent phenomenon (1). Reports on PSA-positive cells in bone marrow (BM) and peripheral blood mononuclear cells are contradictory (2)(3)(4)(5)(6). The elucidation of this controversy might be of clinical utility to establish the nonspecificity of PSA as an indicator of micrometastases (7)(8). Belonging to a large study project on the extraprostatic expression of PSA, we …
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