Prostate Specific Antigen as Predictive Factor for Androgenemia in Women

Abstract

Background: Sex hormones of steroid origin - androgens, play an important role in the life of thebody. They are involved in the regulation of bone maturation, gonadotropin secretion and the synthesisof high-density lipids, the production of β-endorphins. Along with the anabolic effect, androgensregulate libido and sexual potency, stimulate the function of the sebaceous glands and hair follicles.At physiological concentrations, androgens participate in the regression mechanism of the follicle inthe ovaries and provide pubic hair and inguinal hair growth .The present study was conducted withthe aim the possibility of using PSA for the diagnosis of hyper androgenic conditions in women. Thestudy included 105 girls aged 17–26 were examined. The concentration in the peripheral blood ofPSA and a androgens, testosterone and DHEA-S, were determined. In addition, the concentration ofthe transport proteins of androgens SHBG and albumin was investigated. The calculation of (FT) and(BT) was carried out according to special computer programs. The aim of this work was diagnostics ofhyperandrogenic conditions in women. The result shows that the concentration of PSA increases withan increase in T peripheral blood, the concentration of PSA increases with an increase in DHEA-S inperipheral blood and the concentration of PSA increases with an decrease in SHBG in peripheral blood.In conclusion, we found that there is a relationship between androgen levels and PSA concentration inperipheral blood, and PSA is a valuable marker in the diagnosis of hyperandrogenism in women.