Abstract
Usually both acute and chronic bacterial prostatitis can be successfully treated with a 28-day course of fluoroquinolones. However, a significant portion of men will develop a recurrent infection. Host factors such as diabetes and urinary tract manipulation predispose patients to develop chronic bacterial prostatitis or an abscess. Pathogen factors such as the ability to form a biofilm and antibiotic resistance also lead to failures. Difficulty achieving adequate antibiotic concentration in prostatic tissue and more virulent bacteria are just two of the factors that make the treatment of chronic bacterial prostatitis more complex and less successful than the treatment of acute bacterial prostatitis. Increasing resistance to fluoroquinolones among bacteria in the Enterobacteraceae family may make treating chronic bacterial prostatitis even more challenging in the future.
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