Abstract
The aim of this study was to conjugate water-soluble CdS quantum dots (QDs) suitable for targeting of human prostate cancer cells. The water-soluble QDs were conjugated with transferring (Tf) or the murine monoclonal antibody, 7E11-C5.3 through the free carboxylic groups covalently attached. The conjugated CdS were characterized by luminescence and Bradford assay to confirm the attachment of the molecules on the surface of the semiconductor nanocrystals. Cytotoxicity studies showed increased cell viability of the conjugated QDs compared to plain QDs. The conjugates were used to label LNCaP prostate cancer cells and after 5 hr incubation were localized in the cell nucleus. The results showed that QD-7E11 conjugates could be used for in vivo diagnostic studies.
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