Prostate Cancer Radiological Estimation of Change in Sequential Evaluation (PRECISE) Magnetic Resonance Imaging Scoring to Predict Clinical Outcomes in Active Surveillance for Grade Group 1 Prostate Cancer

Abstract

To determine whether radiological change on serial multiparametric magnetic resonance imaging (mpMRI) scored using the Prostate Cancer Radiological Estimation of Change in Sequential Evaluation (PRECISE) Scoring system predicts grade reclassification (GR) at surveillance biopsy in men on active surveillance (AS) with Grade Group 1 (GG1) prostate cancer (PCa). We retrospectively reviewed records of 255 men with low risk PCa on AS with MRI-informed diagnostic (DB) and confirmatory biopsies (CB) and studied the subset who had surveillance biopsies (n = 163) within 6 months of their interval MRI. We studied 309 PRECISE scores in 255 men. 14% demonstrated radiological progression (PRECISE 4-5) on interval MRI performed within 24 months, compared to 34% of those whose interval MRI was performed at a > 3-year interval (p=0.002). 28% (46/163) of men undergoing surveillance biopsy experienced GR to ≥ GG2 PCa. There was no significant increase in the rate of GR with increasing PRECISE score (PRECISE 1-2: 24%, PRECISE 3: 23%, PRECISE 4-5: 38%; p= 0.11). There was a significant increase in the rate of GR with increasing PI-RADS score (p < 0.05). On multivariable analysis, a PI-RADS score of 4-5 was significantly associated with GR compared to men who had a highest PI-RADS ≤ 3 (OR = 1.98 [95% CI: 1.45 - 3.09, p= 0.01]). In a low risk AS cohort with limited follow-up, a patient's highest PI-RADS rather than their PRECISE score on interval MRI was predictive of GR on surveillance biopsy.