Abstract
Background: Genome-wide association studies (GWAS) have identified >100 prostate cancer (PrCa) susceptibility loci, capturing 35% of the PrCa familial relative risk (FRR) within European-ancestry populations. To further elucidate the missing FRR we conducted the largest known PrCa GWAS of ∼47,000 cases and ∼28,000 controls among individuals of European descent using the OncoArray, a platform consisting of a 260K GWAS backbone and 310K custom content selected from previous GWAS of multiple cancers.
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