Abstract
The role of PG and myocarial contractile function in STREP shock has not been reported. To evaluate this phenomenon, rabbits were instrumented to measure mean arterial pressure (MAP), pulmonary artery pressure (PAP), cardiac output (CO), heart rate (HR), left ventricular end diastolic pressure (LVEDP) and dP/dt and to calculate total peripheral (TPR) and pulmonary vascular resistance (PVR) before and after STREP (1012 cells/Kg) infusion. The table shows the effect on the various parameters of indomethacin (IND) pretreatment (4 mg/Kg; GpII) on STREP induced changes from the basal (BASE) values (GpI). *=P<0.05 vs BASE. Values are X̄ ±SEM.LVEDP and TPR remained unchanged and afterload did not increase in either group after STREP infusion. The table shows that IND (GpII) prevented STREP-induced decreases in dP/dt and HR, and increase in PVR (GpI). Thus, we conclude that: 1) STREP infusion illicits a dramatic fall in myocardial contractility that appears to be an important component of the shock process, and 2) STREP-induced changes in contractility and PVR appear to be PG dependent.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
