Abstract
AbstractThe search for noncholinergic, nonadrenergic neurotransmitters in the lower urinary tract has recently focused on the prostaglandins (PG). Prostaglandin E2 (PGE2) and, to a lesser degree, prostaglandin FZα (PGFzα), are produced by the bladder in response to mechanical and nerve stimulation. In vitro stimulation of detrusor smooth muscle, using the same two compounds, produces a slow, prolonged contraction which is independent of nervous activity. In contrast, in urethral smooth muscle PGF2α causes contraction while PGE2 causes relaxation. Clinically, intravesical or intravenous administration of PGE2 or PGF2α may produce improved bladder tone or uninhibited contraction. Similarly, inhibitors of PG synthesis may produce improvement of unstable bladder.
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