Abstract
Mossy fiber nerve endings were isolated from rat hippocampi and used to determine the effects of receptor activation on the production of prostaglandin F 2α (PGF 2α). Glutamate and its agonists had no effect on PGF 2α synthesis. Similarly, acetylcholine, gamma-aminobutyric acid, histamine and purinergic receptor agonists did not affect PGF 2α accumulation in this preparation. However, norepinephrine, serotonin and dopamine exerted receptor-mediated stimulations of PGF 2α production. The agonist-evoked increases in PGF 2α production were attenuated by phospholipase A 2 inhibitors, L-type voltage-sensitive Ca 2+ blockers and a K + channel activator, but they were insensitive to tetrodotoxin. In addition, a kappa opioid agonist decreased PGF 2α synthesis in unstimulated and depolarized synaptosomes. It appeared, therefore, that certain receptor agonists were able to modulate PGF 2α synthesis in the hippocampal mossy fiber synaptosomol preparation.
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