Abstract
Abortion or delivery were induced by extra-amniotic instillation of Rivanol during the second trimester in twelve patients and during the third trimester in two patients with fetal death and one patient with fetal acrania. Serial sampling of amniotic fluid was performed through a transabdominal catheter and the levels of free arachidonic acid (AA), prostaglandin F 2α (PGF 2α), prostaglandin E 2 (PGE 2), 6-keto-prostaglandin F 1α (6-keto-PGF 1α) and thromboxane B 2 (TXB 2) were determined. The levels of AA, PGF 2α, PGE 2, 6-keto-PGF 1α and TXB 2 in amniotic fluid increased significantly during induction with the exception of AA in fetal death which was high and remained constant during induction. Furthermore, PGF 2α, 6-keto-PGF 1α and TXB 2 were all significantly correlated to AA. These observations suggested that free AA is released during Rivanol-induction of abortion and labour giving an increased synthesis of PGF 2α, PGE 2 prostacyclin and thromboxane A 2 in the fetal membranes and the decidua but not in the fetus. This increase might be relevant for the initiation and progress of abortion and labour in these patients.
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