Abstract
Lung primary carcinomas and normal tissue from 136 patients have been extracted for prostaglandins, and the findings examined in relation to histology. In most cases, tumours yielded more prostaglandin-like material (PG-lm), as judged by bioassay, than did normal tissue from the same lungs. Amounts varied with tumour types, in the following ascending order: small-cell carcinomas, large-cell undifferentiated carcinomas, well-differentiated squamous carcinomas, poorly-differentiated adenocarcinomas, poorly differentiated squamous carcinomas, and well-differentiated adenocarcinomas. Tumour PG-lm was highest when necrosis or the neutrophil content of the tumours were moderate, whereas PG-lm from normal lung tissue correlated with the number of macrophages. Chromatography indicated the presence of various prostaglandins, in agreement with our recent findings using gas chromatography--mass spectrometry.
Highlights
PATIENTS AND METHODSThe studies were carried out on tissue from 171 patients undergoing pneumonectomy or lobectomy for lung cancer at the Brook Hospital, London
Summary.-Lung primary carcinomas and normal tissue from 136 patients have been extracted for prostaglandins, and the findings examined in relation to histology
We report investigations of prostaglandins extracted from different types of lung carcinoma, and relate them to histological features
Summary
The studies were carried out on tissue from 171 patients undergoing pneumonectomy or lobectomy for lung cancer at the Brook Hospital, London. The remaining portion was homogenized in Krebs solution alone which allows new prostaglandin synthesis from endogenous precursors released during homogenization (Bennett et al, 1973) This PG-lm is referred to as "total" since it reflects amounts of newly synthesized + basal PG-lm. One paraffin section of tumour and normal lung, made from each tissue taken adjacent to the specimens extracted for prostaglandins, was stained with haematoxylin and eosin. The amount of necrosis, and the numbers of mitotic figures, macrophages, neutrophils andlymphocytes, were assessed independently by 2 histologists (W.F.W. and F.W.) by visual examination of the tissue sections, using a scoring system of 0, + or + + These assessments mean respectively none, few or many seen on a careful but not exhaustive examination of one slide per specimen, made without prior knowledge of the prostaglandin values. The results are presented as median values with semiquartile ranges in parentheses, except where stated otherwise
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