Abstract
This study described the synthesis of prostaglandins (PGs) by the vascular structures of the inner ear (lateran wall = strial vascularis and spiral ligament) in vitro. The main PGs produced were PGI 2, PGF 2α and PGE 2. PGI 2α were also found in the perilymph. A 350 mg/kg ip injection of aspirin decreased PG synthesis by the lateral wall and PG levels in perilymph. This effect was reversed after 3 days. Gentamicin (10 −9 to 10 −5 M) decreased significantly and reversibly PG synthesis in vitro, as did 100 mg/kg ip injection. Acoustic stimulation increased ex vivo PGI 2 and PGE 2 synthesis without modifying PG levels in perilymph. Results suggest that PGs could be one humoral mediator of the cochlear microcirculation homeostasis, and, possibly, of the circulatory disturbances reported after acoustic stimulation. The decreased PG synthesis after gentamicin treatment could account for the angiotoxic component observed in amonoglycoside ototoxicity.
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