Abstract
Two types of oligomeric derivatives of prostaglandin E 1 were synthesized; a free-acid type and a lipophilic ester type. Neither compound inhibited sickling of red blood cells from sickle cell anaemia patients. However, both were found to inhibit the in vitro formation of dehydrated, dense cells (DC) caused bv repeated cycles of sickling and unsickling of sickle cells. Both inhibited the formation of DC in a dose-related manner, but the ester type compound was more effective than the acid-type compound. Concentrations at which these compounds inhibit the DC formation by 50% were 5.2 μM and 40 μM for ester and free-acid compounds, respectively. A possible inhibition mechanism is discussed.
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