Abstract
Serial levels of PGF were quantitated by radioimmunoassay in the serum of 8 ewes during an induced estrous cycle. Daily samples were obtained via chronic catheterization of the inferior vena cava. Mean PGF levels increased throughout the cycle. In addition, a highly significant peak in the mean PGF level occurred on Day 13 following estrus (Day 12 following the serum LH peak) at a time when luteal progesterone levels remained stable. These observations tend to cast doubt on the physiologic role of PGF as the uterine luteolytic factor.
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