Abstract
Prostaglandin F 2α (PGF 2α) (1–100 ng) and acetylcholine (ACh) (0.3–30 μg) injected selectively into the artery supplying the submaxillary gland of the dog produced salivation and an increase in blood flow. Both salivary and vascular responses to PGF 2α developed slowly and lasted long as compared with those to ACh. On a weight basis PGF 2α was about 1000 times more potent than ACh in producing salivation. Upon repeated injections of PGF 2α most glands developed moderate desensitization to PGF 2α but not to ACh. Both salivary and vascular responses to PGF 2α were abolished by infusion of tetrodotoxin ( or 0.1 or 0.2 μg/min), whereas those to ACh remained virtually unchanged. These results indicate that in the dog submaxillary gland PGF 2α causes salivation and vasodilation exclusively through excitation of the parasympathetic postganglionic neurons.
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