Abstract
The presence of prostaglandin F 2 ∝(PGF 2 ∝) in extracts of uterine horns removed from ovariectomized rats, from non-ovariectomized rats and from ovariectomized rats injected with 17-beta estradiol, was studied. Thin-layer chromatography determinations demonstrate the presence of PGF 2∝ in extracts of uterine horns from ovariectomized animals and ovariectomized animals injected with a very small dose of 17-beta estradiol (0.1 ug/day/3 days) but not in extracts from non-ovariectomized or from ovariectomized rats injected with a higher dose of the hormone (60 ug/day/3 days). The relative Isometric Developed Tension (IDT), expressed on dry tissue weight basis, as well as the stability of the IDT and of the frequency of contractions of myometrial strips isolated from castrated rats, were greater than those exhibited by preparations from non-castrated animals and from castrated animals injected with 17-beta estradiol (60 ug/ day/3 days). The influence of ovarian hormones on uterine PGF 2∝ and the possibility of some interrelation between uterine PGF 2∝ and the functional activity of isolated rat myometrium, is discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
