Abstract
In recent years, weaning from the cardiopulmonary bypass in open heart surgery has been made easy by the development of myocardial protection, and postoperative cardiac failure has decreased as well", However, weaning from the cardiopulmonary bypass has continued to be difficult in patients with decreased cardiac function or myocardial damage before surgery;!. Prostaglandin E l (PGE l ) has a number of potent biological actions including direct relaxing effects on vascular smooth musclesa5 • PGE1 is applied in the neonate to maintain the patency of the ductus arteriosus", and also beneficial effect of PGE1 has been reported in patients with congestive heart failure", However, the exact mechanism of the latter effect remains unknown as the potent vasodilating property. PGE1 would likely change the cardiac loading conditions and mask an eventual positive inotropic effect.
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