Prostaglandin E-major urinary metabolite versus fecal immunochemical occult blood test as a biomarker for patient with ulcerative colitis

Natsuki Ishida,Takuma Kagami,Ryosuke Takano,Ken Sugimoto,Hiroaki Miyajima,Takahiro Miyazu,Takahisa Furuta,Satoshi Osawa,Shinya Tani,Mihoko Yamade,Satoshi Tamura,Yasushi Hamaya,Moriya Iwaizumi

doi:10.1186/s12876-020-01256-5

Abstract

BackgroundProstaglandin E-major urinary metabolite (PGE-MUM) may be a novel biomarker for evaluating disease activity in ulcerative colitis (UC). We compared its usefulness to that of the fecal immunochemical occult blood test (FIT).MethodsPGE-MUM and FIT measurements were performed of 92 urinary and fecal samples obtained from 60 patients with UC. Endoscopic activity was determined by Mayo endoscopic subscore (eMayo) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS) score.ResultsPGE-MUM levels and FIT results showed a significant correlation with respect to eMayo (P < 0.001 and P < 0.001, respectively), and there was a significant difference in PGE-MUM values between the groups below eMayo1 and above eMayo2 (P = 0.012). Both biomarkers were significantly correlated with the UCEIS score (P < 0.001 and P < 0.001, respectively), and the PGE-MUM values were significantly different between groups below UCEIS1 and above UCEIS2 (P = 0.012). PGE-MUM and FIT were significantly correlated with eMayo in the group with a disease duration < 5 years (P = 0.041 and P < 0.001, respectively). Although PGE-MUM and eMayo differed significantly between groups over 5 years (P = 0.012), FIT was not correlated with eMayo (P = 0.101).ConclusionsPGE-MUM is useful as a biomarker as FIT for evaluating the endoscopic activity, particularly in long-term affected patients with UC.

Highlights

Prostaglandin E-major urinary metabolite (PGE-MUM) may be a novel biomarker for evaluating disease activity in ulcerative colitis (UC)
Ulcerative colitis (UC) is an idiopathic chronic inflammatory disorder characterized by diarrhea, bloody stool, abdominal pain, fever, anemia, and weight loss [1], and its clinical course is characteristic of repeating remission and relapse [2]
Assessing the disease activity and response to treatment is important to achieving better disease control, current studies have recommended that achieving mucosal healing is the treatment goal of UC since it is associated with sustained clinical remission, decreased hospitalization rates, and the avoidance of colectomy [3]

Summary

Introduction

Prostaglandin E-major urinary metabolite (PGE-MUM) may be a novel biomarker for evaluating disease activity in ulcerative colitis (UC). Fecal samples can be more difficult to obtain than blood or urine samples because patients are reluctant to bring fecal samples to the hospital and it is difficult to collect fecal sample from diarrhea stool These problems can be circumvented by examinations using urine samples. Arai et al reported that prostaglandin E-major urinary metabolite (PGE-MUM) was a reliable biomarker of the colonoscopic and histological appearance of UC, suggesting that it was more sensitive than those previously utilized to evaluate UC-related mucosal inflammation [9].

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Results

Conclusion