Abstract
MRL 1 mice develop an autoimmune, lupus-like disorder characterized by massive proliferation of T cells and rapidly fatal immune complex nephritis. Prostaglandin E 1 (PGE 1), in pharmacologic quantities, retarded the development of this syndrome. The beneficial effects included: (1) increased lifespan, (2) prevention of peripheral T lymphoid hyperplasia, (3) preservation of T-cell mitogenic responses, (4) inhibition of immune complex-mediated glomerulonephritis, and (5) reduction in the amounts of circulating gp70-anti-gp70 immune complexes and of IgG1 and IgG2b. These studies suggest that the protective effects of PGE 1 are related to the inhibition of lymphoid hyperplasia and the consequent prevention of renal disease.
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