Abstract
The effect of prostaglandin D 2 (PGD 2) on vasoactive intestinal polypeptide (VIP) release from the hypothalamus was examined by determining plasma VIP levels in rat hypophysial portal blood. Intraventricular injection of PGD 2 (5 μg/rat) caused a 3-fold increase in the concentration of plasma VIP in hypophysial portal blood in anesthetized rats. A PGD 2 metabolite, 13,14-dihydro-15-keto PGD 2, did not affect VIP levels in portal blood. The flow rate of hypophysial portal blood was not changed after the injection of PGD 2. The intraventricular injection of PGD 2, but not PGD 2 metabolite, resulted in an increase in peripheral plasma prolactin (PRL) levels in the rat. These findings suggest that PGD 2 plays a stimulatory role in regulating VIP release from the hypothalamus into hypophysial portal blood and causes PRL secretion from the pituitary in rats.
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