Abstract
Intragingival injection of one percent carrageenan solution in anesthetized dogs caused an increase in prostaglandin‐like activity in the injected gingiva and a two phase increase in sulcular flow. The first phase was not inhibited by either the prostaglandin synthetase inhibitor indomethacin or the antihistamine pyrilamine. The second phase of increased flow, which was temporally correlated with increased gingival prostaglandin‐like activity, was inhibited by indomethacin, but not by pyrilamine. These results suggest that the increase in gingival sulcular flow in this model of inflammation may be, at least in part, related to increased prostaglandin concentrations.
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