Abstract
The biological activities of 8,12-diiso-PGE 2 (ent-11,15-epi-PGE 2), PGE 2 and PGF 2α have been compared in a series of pharmacological preparations intended to differentiate between F and E type of activity. Similar to PGF 2α but unlike PGE 2, 8,12-diiso-PGE 2 increased the tone of isolated smooth muscle preparations of guinea pig trachea, guinea pig colonic circular layer, rabbit Fallopian tubes. The stimulating effect of 8,12-diiso-PGE 2 and PGF 2α on visceral smooth muscle was also shown in vivo: the two drugs were in all instances able to increase the miogenic activity and tone of rabbit uterus in situ, while these were depressed by PGE 2. 8,12-diiso-PGE 2 decreased pulmonary compliance and increased pulmonary vascular resistance in the anaesthetized cat; PGE 2 always decreased pulmonary vascular resistance, while leaving pulmonary compliance unaltered. The possibility is suggested that 8,12-diiso-PGE 2 acts on PGF receptor in different tissues.
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