Abstract
Glucocorticoids are known mediators of small intestinal maturation. In this study, the effects of exogenously administered HC and PGI2 on BBMP and DNA synthesis along with other indices of maturation were evaluated. Suckling rats were administered PGI2, HC or saline between days 10 to 13 of life and sacrificed on day 14. DNA and BBMP synthesis were analyzed using in vivo 3H-thymidine and 3H-leucine incorporation into DNA and BBMP in separate groups of animals. DNA synthesis was not significantly altered by PGI2 or HC. The ratio of 3H-leucine incorporation into BBMP to total intestinal homogenate protein was elevated in both PGI2 and HC administered animals as follows:RNA and RNA to DNA ratios were elevated in animals administered PGI2 or HC. Intestinal lactase was elevated in PGI2 administered animals, whereas, sucrase, maltase and enterocyte turnover time was considerably less in PGI2 than in HC administered littermates. These data suggests a preferential stimulation of brush border to total intestinal protein synthesis. A specific effect of PGI2 on lactase and HC on sucrase is also suggested.
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