Prospects of quercetin’s using as an active ingredient of soft medicinal forms for the treatment of burns wound (literature review)

Abstract

The problem of treatment of burn wounds in Ukraine and in the world was shown. Every year in Ukraine more than 20,000 adults and 10,000 children need inpatient treatment for burn wounds. The frequency of burn injuries in the developed countries of the world reaches one per 1 thousand population. In the USA about 200,000 people get burns every year, half of them require hospitalization. In Great Britain, about 250,000 people receive care every year, of which 175,000 people sought emergency inpatient care. One of the means of conservative treatment of burn wounds is soft medicinal forms in the form of ointments, creams, gels, balms, etc. with wound-healing, antiseptic and/or antimicrobial properties. Analysis of the nomenclature of soft medicinal forms for the treatment of burn wounds, which are using in Ukraine, shows that none of them contain quercetin. Significant interest of researchers in the study of the local wound-healing effect of quercetin and its mechanisms has been demonstrated. Demonstrated the flavonoid quercetin is found in many plants and has proven broad pharmacodynamics due to the peculiarities of the molecular structure. The quercetin molecule contains a phenolic group and double bonds that bind free radicals, transition metal ions, which affects the processes of oxidation and phosphorylation. Thanks to this, quercetin exhibits powerful antioxidant, membrane stabilizing and cytoprotective effects, which play a significant role in the mechanism of antioxidant, anti-inflammatory, antiallergic, antimicrobial and reparative action. This provides a significant wound-healing activity of quercetin in the local treatment of the wound process due to atopic dermatitis, eczema, cold and thermal burns. The conducted analysis and generalization substantiate the relevance, expediency and timeliness of the search and creation of new soft forms of medicines containing quercetin for the treatment of burn wounds. Keywords: flavonoid quercetin, ointments and gels, wound-healing effect, antioxidant and cytoprotective activity.