Abstract
The article deals with sociomedical questions of secondary osteoporosis occurrence in HIV-infected. It is found that it is a consequence of both the existing AIDS disease and antiretroviral therapy. The normative and legal documents in the field of counteracting HIV infection during the formation of the state policy of Ukraine have been analyzed. Data are given on the study of various aspects of the epidemic nature of the spread of HIV in Ukraine from 1995 to today. The measures of the National target social program of counteracting HIV / AIDS for 2014-2018 are considered. The risk factors and mechanisms of osteopenia/osteoporosis development in HIV-infected patients are described. Objective. Determination of the prospects for the use of health-improving technologies in osteoporosis prevention in HIV-infected. Methods. Analysis and generalization of scientific and methodical literature. Results. It is established that among the causes that lead to bone density disorders, the development of osteoporosis and the occurrence of fractures, in addition to HIV infection and therapy with antiretroviral drugs, a vital role belongs to the way of life of a person (his physical and social activity, peculiarities of nutrition, harmful habits, etc.). It was found that HIV-infected people do not adhere to a healthy lifestyle based on the following criteria: lack of motor activity, smoking, alcohol and drug abuse, malnutrition, and lack of positive health motivation. It is emphasized that timely diagnostics with the help of modern highly informative methods, a balanced approach to the appointment of a choice of antiretroviral therapy scheme, targeted prevention will help to prevent the development of osteoporosis, fracture, disability and improve the quality of life of HIV-infected in general. The main attention is paid to the analysis of methods for the prevention of osteoporosis and its complications. Prospects for the use of regular physical activity, risk factor upgrading and healthy lifestyle promotion are considered in order to prevent bone marrow durability in HIV-infected patients who are only initiating antiretroviral therapy (ART) and are at risk of osteoporosis as a manifestation of side effects of recommended antiretroviral drugs.
Highlights
Decreased bone mineral density in HIV-infected patients is independent of antiretroviral therapy
A. Characteristics of foot fractures in HIV-infected patients previously treated wirt tenofovir versus non-tenofovir-containing highly active antiretroviral therapy / A
Summary
Із статистичних даних відомо про ускладнення з боку кісткової тканини у ВІЛ-інфікованих осіб: поширеність остеопенії вища приблизно на 25 %, остеопорозу – на 15 %, ніж у неінфікованої популяції [16, 27]. Розвитку остеопорозу у ВІЛ-інфікованих пацієнтів сприяють класичні чинники ризику, такі як вік, дефіцит вітаміну Д, знижений рівень споживання кальцію, тютюнопаління, зловживання алкоголем, недостатня фізична активність, низька маса тіла Підтвердженням того факту, що застосування інгібіторів протеази супроводжується підвищенням ризику переломів, служать результати дослідження, отримані на 40 000 ВІЛ-інфікованих ветеранів та на пацієнтах, що отримали схему АРТ на основі тенофовіру, відносно пацієнтів, які не отримували тенофовір [29].
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