Abstract
It has been established that disintegrated membranes (DM) of pseudotuberculosis and intestinal Yersiniosis microbes can be used to produce highly active hyperimmune sera. Hyperimmune serum obtained as a result of immunization of rabbits with pseudotuberculosis DM showed specificity for Yersinia pseudotuberculosis cells, and serum obtained by immunization with intestinal Yersinia DM interacted in ELISA with Yersinia enterocolitica and Yersinia pseudotuberculosis cells. Antibody titers with bacterial cells of other genus of intestinal microflora were low, which allows the use of the obtained hyperimmune sera to create diagnostic yersiniosis test systems with specific and generic specificity.
Highlights
The causative agents of intestinal yersiniosis and pseudotuberculosis affect humans and animals
We present the results of an assessment of the antigenic properties of disintegrated membranes (DM) of pseudotuberculosis and intestinal Yersinia microbes, as well as antibodies obtained as a result of immunization of rabbits with these drugs
As can be seen from the results presented in table 1, DM have a high antigenic activity, which is manifested in reactions with pseudotuberculosis and intestinal yersiniosis commercial serum
Summary
The causative agents of intestinal yersiniosis and pseudotuberculosis affect humans and animals. They can circulate in the warm-blooded body separately from each other or together [1,2,3,4,5,6,7,8]. The main clinical sign in the infection of young farm animals by Yersinia enterocolitica (Y. enterocolitica) and Yersinia pseudotuberculosis (Y. pseudotuberculosis) is diarrhea. This clinical sign is characteristic of many intestinal infections, which increases the importance of laboratory diagnostics for yersiniosis. The development of new drugs for serological diagnosis of yersiniosis is ongoing [9,10,11]
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