Abstract
In this work we carried out studies of the first obtained micellar composition of fatty acid esters with allantoin on a water basis to determine its local irritant effect and therapeutic efficacy in the treatment of burns. It was found that there was a sequential change in the phases of the burn wound process in all groups. During the observation period, wound suppuration was not observed; there were 4 cases of a complicated course of the wound process and a fatal outcome in the control group. When conducting studies of local irritant effects, the assessment was carried out in points, in the experimental group it was on average 2 points as for the animals of the control group. The conducted studies allow us to conclude that the drug, when applied to the skin according to the interstate standard GOST ISO 10993-10—2011, has a weak degree of response to irritation in guinea pigs. The application of a permissive dose of the drug to sensitized guinea pigs does not cause a response from the skin, which indicates the absence of allergenic properties in this composition.
Highlights
One of the important problems of veterinary medicine for many years has been the search for effective methods of treating infected wound processes in tissues [1]
This is due to the fact that the course of the wound process and the presence of anaerobic, aerobic microflora in the foci of infected inflammation lead to disruption of tissue respiration in the healing areas causing disturbances in the surrounding tissues, which result in the development of acidosis, hypoxia and metabolic intoxication of the body [1, 2]
We have developed a prototype of a wound-healing preparation based on fatty acid esters
Summary
One of the important problems of veterinary medicine for many years has been the search for effective methods of treating infected wound processes in tissues [1]. This is due to the fact that the course of the wound process and the presence of anaerobic, aerobic microflora in the foci of infected inflammation lead to disruption of tissue respiration in the healing areas causing disturbances in the surrounding tissues, which result in the development of acidosis, hypoxia and metabolic intoxication of the body [1, 2]. A promising direction is the development and application of multidirectional ointments that combine properties of antimicrobial activity, high dehydrating capacity, stimulation of tissue regeneration would be a source of investigation [6,7,8,9,10]
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