Abstract
The authors are not native speakers of Turkish
 
 The purpose of this literature review was to systematize data from studies of the biological activity of 1,2,4-triazole derivatives with substituents in positions 4 and 5. The authors set the task of forming an idea of current directions in the selection of substitutions for 1,2,4-triazole based on research. 
 As a result of the study, 75 literature sources were analyzed. This made it possible to form a further vector in terms of searching for biologically active structures among 1,2,4-triazole derivatives. The review develops a modern approach to the search for biologically active substances among 1,2,4-triazole derivatives. Systematized data on the nature of substituents in the core of 1,2,4-triazole, which affect a specific type of activity.
 The search material was selected over the past decade with the highest number of citations at the time of literature analysis.
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