Prospects for the pharmacological application of N-acyle-thanolamines of polyunsaturated fatty acids in the therapy of respiratory diseases on the example of bronchial asthma

Abstract

Introduction. At present, the mechanisms of the processes of resolving chronic inflammation in asthma are not fully understood. A search for new pharmacological preparations and substances for the treatment and control of the course of asthma is required. Promising in this direction are N-acylethanolamines (NAE) of polyunsaturated fatty acids - bioactive lipid molecules that exhibit many signaling functions. NAEs are capable of influencing the synthesis of pro-inflammatory cytokines and are also appear to be a substrate for the synthesis of pro-permissive lipid signaling molecules. This review collects data on NAE, provides an overview, biosynthesis, and describes their anti-inflammatory effects.Aim. Summarizing the data of domestic and foreign researchers on the possibility of NAE in the treatment of respiratory diseases on the example of bronchial asthma.Materials and methods. The review uses data from articles published in PubMed, Google Scholar, eLIBRARY.Results. The study and compilation of literature on this issue made it possible to conclude that synthetic NAEs are promising pharmacological objects for asthma therapy, however, further testing of the anti-in­flammatory effects of NAEs and the establishment of the molecular mechanism of their action on inflammation processes are needed.