Prospects for an advanced heavy ion therapy center in the Chicago area

Abstract

Argonne National Laboratory (ANL) and the Department of Radiation and Cellular Oncology at the University of Chicago (UChicago) are investigating the feasibility of developing an innovative heavy ion therapy center by combining an advanced compact heavy ion linac (ACCIL) designed at Argonne with real-time image-guided therapy. The proposed technology will not only be the first linac-based heavy-ion therapy technology in the world, with the advantage of much desired fast energy and ion switching capability, but also the first real-time image-guided heavy ion therapy modality. ANL has a prime location to house such a development within existing infrastructure and radiation enclosure at the former Intense Pulsed Neutron Source (IPNS) site. The cost of developing the technology and building a linac-based ion therapy facility on the existing ANL site will be significantly lower than the “green field” carbon ion therapy centers proposed elsewhere. Such a facility would prove a unique platform to stage the development of pre-clinical studies to prepare for Federal Drug Administration (FDA) clearance for carbon and other ion beam therapies in the US, and pave the way to establishing a clinical therapy facility in the Chicago area. In addition to discovery science in high-gradient accelerator physics and the development of superconducting heavy-ion gantry for therapy delivery coupled with real-time guidance, the proposed facility will enable a breadth of research and applications, and as such, will serve as the advanced particle therapy research center in the US. Potential research topics include cellular radiobiology comparative studies of different ion beam therapies and the development of real-time imaging for precise and accurate dose delivery. The ANL/UChicago Advanced Heavy Ion Therapy Center initiative has recently grown to include the regional and nationwide interest, support and collaboration of Northwestern University, the Chicago Proton Center, the Hines Illinois branch of the Department of Veteran Affairs (VA), as well as the National Center for Particle Beam Radiation Therapy Research.