PROSPECTOR: A Global, Prospective Study To Determine The Prevalence Of The KIT D816V Mutation In Peripheral Blood (PB) From Patients With Evidence Of Systemic Mast Cell Activation (MCA)

Abstract

Systemic MCA is a defining characteristic of patients with MCA syndromes (MCAS). MCAS is a heterogeneous group of mast cell disorders that can be further classified as clonal or non-clonal based on presence or absence of KIT D816V mutation or aberrant CD25 expression on mast cells. The prevalence of clonal mast cell disease with evidence of systemic MCA is unknown. PROSPECTOR (NCT04811365) is a global, multi-center screening study determining prevalence of KIT D816V mutation in PB in patients with evidence of systemic MCA.