Abstract
This study was performed to identify the factors affecting prognosis of oral cancer patients. 1240 pathologically confirmed oral cancer patients were included. The sociodemographic and clinical characteristics of all patients were collected. Univariate and multivariate Cox proportional hazards models were used to assess potential prognostic factors for survival. 1240 oral cancer patients were followed up for 49235.00 person months, and the 5-year overall survival rate was 64.38%. Both univariate and multivariate Cox regression analysis indicated that Body Mass Index < 18.5 kg/m2 (vs 18.5–23.9 kg/m2), age ≥ 55 years (vs < 55 years), clinical stages of II-IV (vs stage I), and poor differentiation (vs well differentiation) were associated with worse survival of oral cancer patients. While surgery (vs non-surgery) and origin of urban area (vs rural area) were protective factors. However, no significant association was found between adjuvant therapy and survival in oral cancer patients.
Highlights
Oral cancer is the most common cancer among head and neck carcinomas, which is becoming a major health problem in developing countries [1]
The objective of this study is to determine whether clinical features, histopathology, and socio-economic status will influence the survival of patients with oral cancer in Southeast China
Univariate analysis of potential prognosis factors in oral cancer patients An univariate Cox regression analysis was performed to test whether the sociodemographic and clinicopathological characteristic selected was associated with survival
Summary
Oral cancer is the most common cancer among head and neck carcinomas, which is becoming a major health problem in developing countries [1]. The prognosis of oral cancer was not significantly improved in the past decades, a relative overall survival rate of 81.7, 61.7 and 54.9% at 1, 3 and 5 years, respectively in the US [3]. Despite being heavily influenced by age, tumor stage, sites, and histological grading, the survival rate of oral cancer patients is influenced by many other factors such as the time between disease and perception, related treatment, access to health-care services, educational levels and occupation of the patients, behavioral/cultural factors, exposure to risk factors such as chewing tobacco [4,5,6,7,8]. The objective of this study is to determine whether clinical features, histopathology, and socio-economic status will influence the survival of patients with oral cancer in Southeast China
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