Abstract
Aim. To evaluate prognostic significance of TSTST in cardiovascular complications development. Material and methods. Totally 162 persons studied, of those 67 with arterial hypertension (AH) and 95 their close relatives of the 1 grade of relativity, healthy at the moment of the first examination in 1998. Second study of the group has been done in 16 years, in 2014. Totally 28 families studied. In 16 years, 101 person had arterial hypertension, and in 34 it had been developed during the observation period. Ischemic heart disease (IHD) was diagnosed in 38 patients, diabetes (DM) — in 21 (all had 2nd type). For 16 years, the brain stroke (BS) developed in 15 participants, in 6 cases it was fatal, and myocardial infarction (MI) — in 13 participants, in 10 cases fatal. Totally 15 patients died (9,3%), one — from melanoma. The participants at the baseline were studied for the TSTST by Henkin R. J. method under Konstantinov E. N. modification. For the second study in 16 years a protocol was created included the results of anthropometric and hemodynamic data, and the cases of AH, IHD, MI and BS, and the death. Results. In the group of those died comparing to the others, were higher levels of TSTST at the baseline (2,52±0,39 vs 1,38±0,16, р<0,05). During 16 years among 54 participants with high TSTST (more than 0,64) died 14 — 25,9%, and from 47 participants with normal TSTST died 1 — 2,13%. In analysis of the influence of TSTST on cardiovascular outcomes, it was shown that the risk of fatal and nonfatal cases of BS increased with TSTST, but the risk of MI did not differ significantly. In addition, the survival of the patients was significantly lower in the case of higher TSTST in BS, as in MI. In survival analysis for the influence of TSTST on nonfatal cases of MI and BS there were no such influence. Conclusion. High TSTST in AH patients increases the risk of fatal and nonfatal cases of BS, fatal MI during 16 years of study. High TSTST is followed by the increase of the risk of new onset of AH, and higher mean values of BP in AH. The decrease of general survival and 16-year survival of AH patients due to fatal cases of BS and MI is caused by higher TSTST.
Highlights
Высокий ПВЧПС у больных АГ повышает риск развития фатальных и нефатальных случаев МИ, фатальных случаев ИМ на протяжении 16 лет наблюдения.
High TSTST in AH patients increases the risk of fatal and nonfatal cases of BS, fatal MI during 16 years of study.
Ранее нами проводилось одномоментное исследование по изучению роли порога вкусовой чувствительности к поваренной соли (ПВЧПС) в АГ и ее осложнений, в котором было показано, что высокие значения ПВЧПС ассоциируются с более высокими значениями артериального давления, избыточным весом, а также в своем формировании зависят не только от средовых влияний, но и имеют генетическую основу [11,12,13].
Summary
Высокий ПВЧПС у больных АГ повышает риск развития фатальных и нефатальных случаев МИ, фатальных случаев ИМ на протяжении 16 лет наблюдения. High TSTST in AH patients increases the risk of fatal and nonfatal cases of BS, fatal MI during 16 years of study. Ранее нами проводилось одномоментное исследование по изучению роли порога вкусовой чувствительности к поваренной соли (ПВЧПС) в АГ и ее осложнений, в котором было показано, что высокие значения ПВЧПС ассоциируются с более высокими значениями артериального давления, избыточным весом, а также в своем формировании зависят не только от средовых влияний, но и имеют генетическую основу [11,12,13].
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