Abstract

692 Background: One way to improve cost-benefit for breast cancer screening in younger women is to identify those at high-risk of breast cancer and manage these women in an optimal manner. The purpose of this study is to evaluate the sensitivity and specificity of Electrical Impedance Scanning (EIS) for identifying young women who are at-risk for having breast cancer and should be followed up with advanced imaging technologies. Methods: A prospective observational two-arm multi-site clinical trial was performed on women aged 30–45 years. Exclusion criteria included: age 45, pregnancy, current cancer treatment, recent breast surgery or biopsy, or implanted electrical device. The “Sensitivity arm” included Clinical Breast Examination (CBE) and EIS on 189 women prior to breast biopsy. The “Specificity arm” included 1,361 asymptomatic women undergoing annual well-woman examination and EIS. Primary endpoints included EIS sensitivity, specificity and risk identifying capability. Relative risk of cancer ...

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