PROSPECTIVE STUDY OF DEVELOPMENT OF CARDIOVASCULAR EVENTS IN RELATION WITH CARDIOVASCULAR RISK (ESSE-RF IN KEMEROVSKAYA REGION)

Abstract

Aim. Evaluation of cardiovascular risk factors influence on the development of cardiovascular events (hospitalization, coronary and carotid surgery, death) in prospective study.Material and methods. Analysis was performed by the results of multicenter epidemiologic study “Epidemiology of cardiovascular diseases and risk factors in Russian Federation (ESSE-RF)” in Kemerovskaya oblast, collected on a random sample of adult inhabitants, age 25-64 y. o. (n=1628). With the first screening, by interviewing, the data collected, on the main cardiovascular risk factors and objective data. In the prospective part of the study, in 4 years after primary screening, in participants and their families the data collected by phone interviewing, on cardiovascular events. Combinational endpoint was evaluated, by the class of cardiovascular pathology: death + hospitalization + surgery on coronary/carotid vessels. Combined influence of the studied factors was assessed with logistic regression.Results. Among the parameters of objective study, statistically significantly influenced the probability of combination endpoint development the age (OR=1,06 in 95% CI 1,02-1,09), male gender (OR=3,79 in 95% CI 1,88-7,61); influence of anamnesis of myocardial infarction is close to significant (OR=2,43 in 95% CI 0,73-8,10). Of the questionnaire-based parameters, significant influences on the probability of combinational endpoint development depression (OR=2,38 in 95% CI 1,32-4,29). Close to significant — absence no family status (OR=1,75 in 95% CI 0,98-3,13) and decreased life quality by EUROQOL-EQ-5D (OR=1,21 in 95% CI 0,98-1,49).Conclusion. A significant impact on the probability of cardiovascular diseases development during 4 year period of the study, do influence the age, male gender and depression.