Abstract
COVID-19 has become a global health concern, due to the high transmissible nature of its causal agent and lack of proper treatment. Early diagnosis and nonspecific medical supports of the patients appeared to be effective strategy so far to combat the pandemic caused by COVID-19 outbreak. Biomarkers can play pivotal roles in timely and proper diagnosis of COVID-19 patients, as well as for distinguishing them from other pulmonary infections. Besides, biomarkers can help in reducing the rate of mortality and evaluating viral pathogenesis with disease prognosis. This article intends to provide a broader overview of the roles and uses of different biomarkers in the early diagnosis of COVID-19, as well as in the classification of COVID-19 patients into multiple risk groups.
Highlights
Biomarkers can play a significant role in the early diagnosis and differentiation of SARS-CoV-2 infection from other pulmonary infections exhibiting almost similar symptoms
Biomarkers have proven to be effective in differentiating between these two classes of patients
Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): evidence from a meta-analysis
Summary
Due to the contagious nature of the virus and lack of any specific approved treatment, it becomes important to ensure early stratification of the infected patients to reduce the risk of transmission among susceptible groups as well as to allocate optimal resources to the patients who are in severe condition. The spread of the virus is so swift that the general population, healthcare professionals and regulatory authorities from different countries have employed vastly different, but effective strategies to battle against the virus In this situation, early diagnosis and effective management of the infected population are critical. Biomarkers can play a key role in this regard by ensuring the efficient diagnosis as well as guiding improvements in the clinical management of patients with COVID-19. The identification of integral biomarkers of the SARS-CoV-2 may facilitate a much more robust response against future respiratory viral outbreaks with the potential of creating global pandemics. The accumulated knowledge regarding SARS-CoV-2 infection biomarkers might be utilized to generate a much more efficient resource allocation in tackling future outbreaks and pandemics and more research works are warranted in this regard
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