Abstract
A contributing factor to poor success rates in IVF may be the suboptimal culture conditions used during fertilization and early embryonic development. This may result in embryos with compromised growth rates and reduced viability. In order to more closely mimic the in vivo preimplantation environment, the culture of embryos on a layer of cells has been developed (coculture). In response to the FDA's 2002 recommendation that only human cell lines be used (due to the concern of xenologous viral transmission) various human cell lines have been studied, in particular autologous endometrial coculture (AECC).
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