Abstract
Purpose: Intraarticular corticosteroid (IACS) injection is often used to manage moderate to severe knee osteoarthritis (OA) pain. Retrospective analyses have raised concerns of potential negative effects on joint structure and progression of OA, but these studies were limited by incomplete radiographic reporting and lack of data on prior IACS treatment. Additionally, patients seeking IACS for pain relief may represent a population with more severe OA and ongoing structural progression. There is a need for prospective clinical trials to assess the immediate and long-term effects of IACS in knee OA.
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