Abstract
1524 Background: To assess QOL and the prognostic importance of QOL in adult patients with newly diagnosed high grade gliomas (HGG), QOL and outcome data collected in three prospective cooperative group clinical trial were analyzed. Methods: The QOL study was a companion protocol for three phase II protocols; 98–72-51 and 98–72-52 examined pre-irradiation and concurrent chemotherapy with radiation therapy for patients with anaplastic astrocytomas and glioblastomas (GBM) respectively, while N0074 investigated maintenance EGFR inhibitor after radiation was completed for GBMs. At study entry and at regular intervals, 5 self-administered forms were completed by the patient to assess (i) overall QOL (Linear Analogue Scale [LASA] and the Functional Assessment of Cancer Therapy-Brain [FACT-BR Version 4]), (ii) fatigue (Profiles of Mood States short form [POMS-SF] and the Symptom Distress Scale [SDS]), (iii) excessive daytime somnolence (Epworth Sleepiness Scale [ESS]), and (iv) depression (Profiles of Mood State...
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