Prospective Evaluation of Venous Excess Ultrasound for Estimation of Venous Congestion

Abstract

Venous excess ultrasound (VExUS) is a novel ultrasound technique previously reported as a noninvasive measure of venous congestion and predictor of cardiorenal acute kidney injury. Are there associations between VExUS grade and cardiac pressures measured by right heart catheterization (RHC) and cardiac biomarkers and clinical outcomes in patients undergoing RHC? We conducted a prospective cohort study at the Denver Health Medical Center from December 20, 2022, to March 25, 2023. All patients undergoing RHC underwent a blinded VExUS assessment prior to their procedure. Multivariable regressions were conducted to assess relationships between VExUS grade and cardiac pressures, biomarkers, and changes in weight among patients with heart failure, a proxy for diuretic success. Receiver operating characteristic curve and area under the curve (AUC) were derived for VExUS, inferior vena cava (IVC) diameter, and IVC collapsibility index (ICI) to predict right atrial pressure (RAP) > 10 and< 7mmHg. Among 81 patients, 45 of whom were inpatients, after adjusting for age, sex, and Charlson Comorbidity Index, there were significant relationships between VexUS grade of 2 (β= 4.8; 95% CI, 2.6-7.1; P< .01) and 3 (β= 11; 95% CI, 8.9-14; P< .01) and RAP, VExUS grade of 2 (β= 6.8; 95% CI, 0.16-13; P= .045) and 3 (β= 15; 95% CI, 7.3-22; P< .01) and mean pulmonary artery pressure, and VExUS grade of 2 (β= 7.0; 95% CI, 3.9-10; P< .01) and 3 (β= 13; 95% CI, 9.5-17; P< .01) and pulmonary capillary wedge pressure. AUC values for VExUS, IVC diameter, and ICI as predictors of RAP > 10mmHg were 0.9 (95%CI, 0.83-0.97), 0.77 (95%CI, 0.68-0.88), and 0.65 (95%CI, 0.52-0.78), respectively. AUC values for VExUS, IVC diameter, and ICI as predictors of RAP< 7mmHg were 0.79 (95%CI, 0.70-0.87), 0.74 (95%CI, 0.64-0.84), and 0.62 (95%CI, 0.49-0.76), respectively. In a subset of 23 patients with heart failure undergoing diuresis, there was a significant association between VExUS grade 3 and change in weight between time of RHC and discharge (P= .025). Although more research is required, VExUS has the potential to increase diagnostic and therapeutic capabilities of physicians at the bedside and increase our understanding of the underappreciated problem of venous congestion.