Abstract
ObjectiveTo improve prediction of sudden cardiac death (SCD) in patients with ischaemic cardiomyopathy (ICM). Electrical heterogeneity is known to contribute to risk of SCD. We have previously developed Regional Restitution...
Highlights
Sudden cardiac death (SCD) is responsible for over 3 million deaths per year worldwide.[1]
Given that the Controls underwent an electrophysiology study (EPS) because of a different indication, there were significant differences in their clinical characteristics and left ventricular ejection fraction compared to the two other groups
Median follow up in the Primary Study group was 23 months [18] during which 6 patients reached the endpoint of ventricular arrhythmia (VA)/death: 3 VA and 4 deaths (1 patient had successful Implantable cardioverter defibrillators (ICDs) therapy for VA and subsequently died)
Summary
Sudden cardiac death (SCD) is responsible for over 3 million deaths per year worldwide.[1]. Body surface measurement of APD restitution has been shown to be possible in a small canine study using a single electrocardiogram (ECG) lead and has been correlated with epicardial unipolar electrograms.[7,8]. The aim of this retrospective study was to develop a new electrophysiological measure of electrical restitution heterogeneity using the surface ECG: the Regional Restitution Instability Index (R2I2), to assess its correlation with cardiac magnetic resonance (CMR) features of increased VA risk and to test and replicate its utility in predicting risk of VA/death in patients with ischemic cardiomyopathy (ICM) who were candidates for ICD therapy.[9,10,11]
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