Abstract
Background: Assessing the relation between arthritis and cognitive impairment could expand the understanding of health consequences of arthritis. The aim was to prospectively examine the association between arthritis and cognitive functions among middle-aged and elderly Chinese.Methods: Our analyses were based on data from the nationwide China Health and Retirement Longitudinal Study (2011–2016). Arthritis was ascertained by self-reported doctor diagnosis during the baseline survey. Cognitive functions were evaluated in three domains including episodic memory, mental status, and global cognition. Linear mixed models were employed to assess the association between baseline arthritis and cognition functions.Results: Of 7,529 Chinese adults, 49.79% were men, and mean age was 57.53 years. During a follow-up of 4 years, participants with baseline arthritis showed lower scores of episodic memory [β = −0.08; 95% confidence interval (CI): −0.14, −0.03], mental status (β = −0.14; 95% CI: −0.22, −0.05), and global cognition (β = −0.22; 95% CI: −0.34, −0.11), compared to those without arthritis. In addition, participants with arthritis showed increased rates of decline in mental status and global cognition by 0.04 (95% CI: 0.01, 0.08) and 0.05 (95% CI: 0.01, 0.09) units per year, respectively.Conclusion: Arthritis was associated with subsequent risk of poorer cognitive functions and slightly faster declines in cognitive functions among Chinese middle-aged and elderly adults. Our findings should be confirmed in future large prospective studies in Chinese and other populations.
Highlights
450 communities of 28 provinces in China in 2011–2012(baseline)
By the Biomedical Ethics Review Committee of Peking University cognitive impairment is emerging as a major population health (IRB00001052-11015) and informed consent was obtained from challenge both in China and worldwide, and investigations for its all participants
During the 4-year follow-up, participants with arthritis at baseline had lower scores in episodic memory (β = −0.08; 95% CI: −0.14, −0.03), mental status (β = −0.14; −0.22, −0.05), and global cognition (β = −0.22; −0.34, −0.11) than those without arthritis (Table 2)
Summary
450 communities of 28 provinces in China in 2011–2012(baseline). Using computer-assisted standardized questionnaires, Cognitive impairment is a common aging-related chronic trained staff collected information in face-to-face interviews condition that can progress as a preclinical stage to dementia on demographic and socioeconomic factors, lifestyles and (Arvanitakis et al, 2019). Mild cognitive impairment is behaviors, and health status and functioning. Blood prevalent in over 10% of people aged 70 years or older In China, the prevalence of mild cognitive Two follow-ups in 2013–2014 and 2015–2016 were completed impairment could reach up to 15% in people aged 60 years or according to similar procedures at baseline, and response rates older (Xue et al, 2018), and the prevalence of dementia was 5.6% were 88.30 and 87.15%, respectively. By the Biomedical Ethics Review Committee of Peking University cognitive impairment is emerging as a major population health (IRB00001052-11015) and informed consent was obtained from challenge both in China and worldwide, and investigations for its all participants.
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