Abstract
Cardiovascular disease (CVD) has been identified as a major contributor to morbidity and mortality in patients with systemic lupus erythematosus (SLE). The etiology of premature CVD in SLE is supposed to have many factors, including traditional coronary artery disease (CAD) risk factors, antiphospholipid antibodies, and metabolic and inflammatory factors. Despite the overwhelming interest in CVD in SLE research, prospective studies evaluating risk factors for hard endpoints (that is, cardiovascular events) are relatively scarce. The article by Gustafsson and colleagues suggests that prothrombotic factors play an important role in SLE-related CVD and that the influence of traditional CAD risk factors might be limited.
Highlights
Cardiovascular disease (CVD) has been identified as a major contributor to morbidity and mortality in patients with systemic lupus erythematosus (SLE)
In a recent issue of Arthritis Research & Therapy, Gustafsson and colleagues [1] presented the results of an interesting prospective study on risk factors for cardiovascular events (CVEs) in 182 Swedish patients with systemic lupus erythematosus (SLE) who were selected to be free of CVEs at inclusion
Gustafsson and colleagues report that 24 out of 182 patients with SLE had at least one CVE after a mean follow-up of 8 years; this equates to the occurrence of one first CVE in 63 patient-years
Summary
Cardiovascular disease (CVD) has been identified as a major contributor to morbidity and mortality in patients with systemic lupus erythematosus (SLE). In a recent issue of Arthritis Research & Therapy, Gustafsson and colleagues [1] presented the results of an interesting prospective study on risk factors for cardiovascular events (CVEs) in 182 Swedish patients with systemic lupus erythematosus (SLE) who were selected to be free of CVEs at inclusion.
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