Prospective close monitoring of the effect of vascular-targeted photodynamic therapy and high intensity focused ultrasound of localized prostate cancer by multiparametric magnetic resonance imaging.

Abstract

The aim of this study is to describe the anatomical and functional changes observed in multiparametric magnetic resonance imaging (mpMRI) during follow-up after focal therapy (FT) for localized prostate cancer (PCa). In this prospective study, we analyzed pre- and postoperatively acquired mpMRI of 10 patients after FT (7days; 3, 6, 9, 12months). 7/10 (70%) patients underwent vascular-targeted photodynamic therapy (VTP). 3/10 (30%) patients underwent high-intensity focused ultrasound (HIFU). MpMR image analysis was performed using a semi-automatic software for segmentation of the prostate gland (PG) and tumor zones. Signal intensities (SI) of T2-weighted (T2w), T1-weighted (T1w),diffusion-weighted (DWI) and dynamic contrast-enhanced (DCE) images as well as volumes of the prostate gland (PGV) and tumor volumes (TV) were evaluated at each time point. The results showed a significant increase of PGV 7days after FT (p = 0.042) and a significant reduction of PGV between 7days and 6, 9 and 12months after FT (p < 0.001). The TV increased significantly 7days after FT (p < 0.001) and decreased significantly between 7days and 12months after FT (p < 0.001). There was a significant increase in SI of the ADC in the ablation zone after 6, 9 and 12months after FT (p < 0.001). 1/9 patients (11%) had recurrent tumor on rebiopsy characterized as a a small focal lesion on mpMRI with strong diffusion restriction (low SI on ADC map and high SI on b-value DWI). MpMRI is able to represent morphologic changes of the ablated zone after FT and might be helpful to detect recurrent tumor.