Abstract
Perturbations in the actions of T3 and T4 influence the normal metabolic pathways. Responsiveness of lipid biomarkers like LDL-C, HDL-C, TC, TG, Apo-A, and Apo-B after rehabilitation of thyroid profile attaining euthyroid state was determined. A total of 179 age-matched subjects of both genders were recruited for this research. Sixty healthy controls, thirty-four subclinical, fifty overt hyperthyroid, and thirty-five follow-up subjects having 3 months of Carbimazole therapy were enrolled. Biochemical analysis was performed by chemistry analyzer, RIA, and ELISA. One-way ANOVA was applied for the statistical analysis, while significance (P < 0.05) of means was compared by the Student-Newman-Keuls (SNK) test. Pronounced reduction (P < 0.001) of cholesterol in overt as compared to control and subclinical was noticed, whereas marked improvement (P < 0.001) was evidenced in follow-up. Prominent elevation (P < 0.05) of TG in follow-up was evidenced as compared to control. Overt presented marked reduction of HDL-C as compared to subclinical and control (P < 0.01 and P < 0.001), respectively. Pronounced elevation (P < 0.001) of HDL-C was evidenced after treatment. Overt presented reduction of LDL-C as compared to subclinical and control (P < 0.01 and P < 0.05, respectively). The follow-up group demonstrated considerable (P < 0.001) improvement of LDL-C after treatment and elevation (P < 0.05) as compared to control. Overt presented reduction of Apo-B as compared to subclinical and control (P < 0.05 and P < 0.001, respectively). Improvement (P < 0.05) of Apo-B was evidenced in follow-up. Reduction (P < 0.05) of Apo-A in overt as compared to control and elevation (P < 0.05) in follow-up as compared to overt was evidenced. Conclusively, improvement after treatment was evidenced in lipid profile.
Highlights
Thyroid hormones both tri-iodothyronine (T3) and tetraiodothyronine (T4) or thyroxin are the most vital biomolecules in the realm of thyroidology [1]. Both T3 and T4 are under the influence of thyroid-stimulating hormone (TSH) a glycoprotein, released by adenohypophysis that in turn is controlled by thyroliberin of the hypothalamus [2]
Nonsignificant difference was present in control vs. subclinical and follow-up comparison; control vs. overt comparison presented marked difference (P ≤ 0:001) with 36% reduction of total cholesterol (TC) level in the overt group when compared with controls
Conclusively, improved lipid biosynthesis has been observed in the follow-up group attaining a euthyroid state
Summary
Thyroid hormones both tri-iodothyronine (T3) and tetraiodothyronine (T4) or thyroxin are the most vital biomolecules in the realm of thyroidology [1]. Both T3 and T4 are under the influence of thyroid-stimulating hormone (TSH) a glycoprotein, released by adenohypophysis that in turn is controlled by thyroliberin of the hypothalamus [2]. Levels of T3 and T4 in circulation execute a negative feedback effect on pars distalis of the pituitary to synthesize TSH, a regulatory hormone, which later acts on the TSH receptor Overt or clinical hyperthyroidism is characterized by elevated serum free T4 and T3 levels in the presence of an undetectable TSH concentration. Indications of hyperthyroidism are loss of weight, increased sweating, tremors of hands, weakness, increased appetite, accelerated heartbeat, loose stools, irritability, exophthalmos, heat intolerance, moist skin, and goiter [5]
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