PROSPECTIVE ANALYSIS OF LIPID SPECTRUM PARAMETERS AND VASCULAR INFLAMMATORY MARKERS AS A VARIANT OF A PERSONIFIED APPROACH TO PROGNOSIS OF UNDESIRABLE CORONARY EVENTS IN PATIENTS WITH CORONARY HEART DISEASE AFTER ANGIOPLASTY

Abstract

The relevance of the study is due to the fact that the ambiguous role of biochemical mediators in the development of angioplasty complications with stenting and the lack of consensus on the timing of laboratory indicators determine to specify the approaches to the study of biochemical parameters that indicate the nature of the course of coronary heart disease (CHD) and the development of possible undesirable complications after percutaneous coronary intervention. This article aims to analyze the parameters of lipid spectrum and markers of vascular inflammatory reaction in patients with CHD, in groups with stable angina and unstable angina episode after angioplasty with stenting, to trace the dynamics of biochemical parameters and to reveal the predictors of undesirable coronary events. Patients with CHD with significant coronary artery stenosis (CKS, n=95) revealed after coronary angiography (CAG) at the point of maximum increase in the markers of the inflammatory response (3 months after angioplasty) are divided into 2 groups – patients with stable angina pectoris (AP, n=77) until the end of the study and patients with a developed post-revascularization episode of unstable angina (UA, n=18) after angioplasty with stenting. It was established that patients with UA at the initial stage have a significantly higher risk of developing coronary blood flow instability in the post-revascularization period due to initially elevated levels of homocysteine and rf-CRP. The results obtained are very important for the implementation of an optimal program for monitoring patients with coronary artery disease, improving measures to increase adherence to therapy at the outpatient stage of treatment.